Anabolic steroid

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Can you send some ideas and pricing plans? Phil and The New York Times. I personally think the frozen meals are a very good add-on as they provide more variety and tend to be a bit more tasty and satisfying. Applied modifications in the steroidal structure". Your very welcome, I'm glad that it was helpful.

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The American College of Sports Medicine acknowledges that AAS, in the presence of adequate diet, can contribute to increases in body weight , often as lean mass increases and that the gains in muscular strength achieved through high-intensity exercise and proper diet can be additionally increased by the use of AAS in some individuals. Health risks can be produced by long-term use or excessive doses of AAS. Ergogenic uses for AAS in sports , racing , and bodybuilding as performance-enhancing drugs are controversial because of their adverse effects and the potential to gain unfair advantage in physical competitions.

Their use is referred to as doping and banned by most major sporting bodies. Since the discovery and synthesis of testosterone in the s, AAS have been used by physicians for many purposes, with varying degrees of success. These can broadly be grouped into anabolic, androgenic, and other uses. Most steroid users are not athletes.

AAS have been used by men and women in many different kinds of professional sports to attain a competitive edge or to assist in recovery from injury. These sports include bodybuilding , weightlifting , shot put and other track and field , cycling , baseball , wrestling , mixed martial arts , boxing , football , and cricket. Such use is prohibited by the rules of the governing bodies of most sports. AAS use occurs among adolescents, especially by those participating in competitive sports.

It has been suggested that the prevalence of use among high-school students in the U. The AAS that have been used most commonly in medicine are testosterone and its many esters but most typically testosterone undecanoate , testosterone enanthate , testosterone cypionate , and testosterone propionate , [63] nandrolone esters typically nandrolone decanoate and nandrolone phenylpropionate , stanozolol , and metandienone methandrostenolone.

Designer steroids are AAS that have not been approved and marketed for medical use but have been distributed through the black market. There are four common forms in which AAS are administered: Oral administration is the most convenient. Testosterone administered by mouth is rapidly absorbed, but it is largely converted to inactive metabolites, and only about one-sixth is available in active form. This modification reduces the liver's ability to break down these compounds before they reach the systemic circulation.

Testosterone can be administered parenterally , but it has more irregular prolonged absorption time and greater activity in muscle in enanthate , undecanoate , or cypionate ester form. These derivatives are hydrolyzed to release free testosterone at the site of injection; absorption rate and thus injection schedule varies among different esters, but medical injections are normally done anywhere between semi-weekly to once every 12 weeks.

A more frequent schedule may be desirable in order to maintain a more constant level of hormone in the system. In addition, because estered testosterone is dissolved in oil, intravenous injection has the potential to cause a dangerous embolism clot in the bloodstream. Transdermal patches adhesive patches placed on the skin may also be used to deliver a steady dose through the skin and into the bloodstream.

There is also the risk that an intimate partner or child may come in contact with the application site and inadvertently dose himself or herself; children and women are highly sensitive to testosterone and can suffer unintended masculinization and health effects, even from small doses. Injection is the most common method used by individuals administering AAS for non-medical purposes.

The traditional routes of administration do not have differential effects on the efficacy of the drug. Studies indicate that the anabolic properties of AAS are relatively similar despite the differences in pharmacokinetic principles such as first-pass metabolism.

However, the orally available forms of AAS may cause liver damage in high doses. Known possible side effects of AAS include: Depending on the length of drug abuse, there is a chance that the immune system can be damaged.

Most of these side-effects are dose-dependent, the most common being elevated blood pressure , especially in those with pre-existing hypertension. AAS have been shown to alter fasting blood sugar and glucose tolerance tests. A number of severe side effects can occur if adolescents use AAS.

For example, AAS may prematurely stop the lengthening of bones premature epiphyseal fusion through increased levels of estrogen metabolites , resulting in stunted growth. Other effects include, but are not limited to, accelerated bone maturation , increased frequency and duration of erections, and premature sexual development. AAS use in adolescence is also correlated with poorer attitudes related to health.

Probably carcinogenic to humans. Other side-effects can include alterations in the structure of the heart , such as enlargement and thickening of the left ventricle , which impairs its contraction and relaxation , and therefore reducing ejected blood volume.

AAS use can cause harmful changes in cholesterol levels: AAS use in adolescents quickens bone maturation and may reduce adult height in high doses. There are also sex-specific side effects of AAS.

Development of breast tissue in males, a condition called gynecomastia which is usually caused by high levels of circulating estradiol , may arise because of increased conversion of testosterone to estradiol by the enzyme aromatase. This side-effect is temporary; the size of the testicles usually returns to normal within a few weeks of discontinuing AAS use as normal production of sperm resumes.

Female-specific side effects include increases in body hair , permanent deepening of the voice, enlarged clitoris , and temporary decreases in menstrual cycles. Alteration of fertility and ovarian cysts can also occur in females. Kidney tests revealed that nine of the ten steroid users developed a condition called focal segmental glomerulosclerosis , a type of scarring within the kidneys.

The kidney damage in the bodybuilders has similarities to that seen in morbidly obese patients, but appears to be even more severe. High doses of oral AAS compounds can cause liver damage. A review in CNS Drugs determined that "significant psychiatric symptoms including aggression and violence, mania , and less frequently psychosis and suicide have been associated with steroid abuse.

Long-term steroid abusers may develop symptoms of dependence and withdrawal on discontinuation of AAS". Recreational AAS use appears to be associated with a range of potentially prolonged psychiatric effects, including dependence syndromes, mood disorders , and progression to other forms of substance abuse, but the prevalence and severity of these various effects remains poorly understood.

Large-scale long-term studies of psychiatric effects on AAS users are not currently available. DSM-IV lists General diagnostic criteria for a personality disorder guideline that "The pattern must not be better accounted for as a manifestation of another mental disorder, or to the direct physiological effects of a substance e. As a result, AAS users may get misdiagnosed by a psychiatrist not told about their habit.

Affective disorders have long been recognised as a complication of AAS use. From the mids onward, the media reported "roid rage" as a side effect of AAS. A review determined that some, but not all, randomized controlled studies have found that AAS use correlates with hypomania and increased aggressiveness, but pointed out that attempts to determine whether AAS use triggers violent behavior have failed, primarily because of high rates of non-participation.

Compared with individuals that did not use steroids, young adult males that used AAS reported greater involvement in violent behaviors even after controlling for the effects of key demographic variables, previous violent behavior, and polydrug use.

The drug response was highly variable. The mechanism of these variable reactions could not be explained by demographic, psychological, laboratory, or physiological measures. A study of two pairs of identical twins, in which one twin used AAS and the other did not, found that in both cases the steroid-using twin exhibited high levels of aggressiveness, hostility, anxiety, and paranoid ideation not found in the "control" twin.

The relationship between AAS use and depression is inconclusive. There have been anecdotal reports of depression and suicide in teenage steroid users, [] but little systematic evidence. A review found that AAS may both relieve and cause depression, and that cessation or diminished use of AAS may also result in depression, but called for additional studies due to disparate data. Androgens such as testosterone , androstenedione and dihydrotestosterone are required for the development of organs in the male reproductive system , including the seminal vesicles , epididymis , vas deferens , penis and prostate.

The pharmacodynamics of AAS are unlike peptide hormones. However, as fat-soluble hormones, AAS are membrane-permeable and influence the nucleus of cells by direct action. The pharmacodynamic action of AAS begin when the exogenous hormone penetrates the membrane of the target cell and binds to an androgen receptor AR located in the cytoplasm of that cell.

From there, the compound hormone-receptor diffuses into the nucleus, where it either alters the expression of genes [] or activates processes that send signals to other parts of the cell. The effect of AAS on muscle mass is caused in at least two ways: It has been hypothesized that this reduction in muscle breakdown may occur through AAS inhibiting the action of other steroid hormones called glucocorticoids that promote the breakdown of muscles.

As their name suggests, AAS have two different, but overlapping, types of effects: Some examples of the anabolic effects of these hormones are increased protein synthesis from amino acids , increased appetite, increased bone remodeling and growth, and stimulation of bone marrow , which increases the production of red blood cells. Through a number of mechanisms AAS stimulate the formation of muscle cells and hence cause an increase in the size of skeletal muscles , leading to increased strength.

The androgenic effects of AAS are numerous. Depending on the length of use, the side effects of the steroid can be irreversible. Processes affected include pubertal growth, sebaceous gland oil production, and sexuality especially in fetal development. Some examples of virilizing effects are growth of the clitoris in females and the penis in male children the adult penis size does not change due to steroids [ medical citation needed ] , increased vocal cord size, increased libido , suppression of natural sex hormones , and impaired production of sperm.

Men may develop an enlargement of breast tissue, known as gynecomastia, testicular atrophy, and a reduced sperm count. Compounds with a high ratio of androgenic to an anabolic effects are the drug of choice in androgen-replacement therapy e. This disassociation is less marked in humans, where all AAS have significant androgenic effects. A commonly used protocol for determining the androgenic: The VP weight is an indicator of the androgenic effect, while the LA weight is an indicator of the anabolic effect.

Two or more batches of rats are castrated and given no treatment and respectively some AAS of interest. Animal studies also found that fat mass was reduced, but most studies in humans failed to elucidate significant fat mass decrements. The effects on lean body mass have been shown to be dose-dependent.

Both muscle hypertrophy and the formation of new muscle fibers have been observed. The hydration of lean mass remains unaffected by AAS use, although small increments of blood volume cannot be ruled out. The upper region of the body thorax, neck, shoulders, and upper arm seems to be more susceptible for AAS than other body regions because of predominance of ARs in the upper body. After drug withdrawal, the effects fade away slowly, but may persist for more than 6—12 weeks after cessation of AAS use.

Overall, the exercise where the most significant improvements were observed is the bench press. The measurement of the dissociation between anabolic and androgenic effects among AAS is based largely on a simple although arguably unsophisticated and outdated model involving rat tissue bioassays.

The intracellular metabolism theory explains how and why remarkable dissociation between anabolic and androgenic effects can occur despite the fact that these effects are mediated through the same signaling receptor, and of course why dissociation is invariably incomplete. An animal study found that two different kinds of androgen response elements could differentially respond to testosterone and DHT upon activation of the AR.

Changes in endogenous testosterone levels may also contribute to differences in myotrophic—androgenic ratio between testosterone and synthetic AAS. Testosterone can be metabolized by aromatase into estradiol , and many other AAS can be metabolized into their corresponding estrogenic metabolites as well.

The major effect of estrogenicity is gynecomastia woman-like breasts. AAS are androstane or estrane steroids. As well as others such as 1-dehydrogenation e.

The most commonly employed human physiological specimen for detecting AAS usage is urine, although both blood and hair have been investigated for this purpose. The AAS, whether of endogenous or exogenous origin, are subject to extensive hepatic biotransformation by a variety of enzymatic pathways.

The primary urinary metabolites may be detectable for up to 30 days after the last use, depending on the specific agent, dose and route of administration. A number of the drugs have common metabolic pathways, and their excretion profiles may overlap those of the endogenous steroids, making interpretation of testing results a very significant challenge to the analytical chemist.

Methods for detection of the substances or their excretion products in urine specimens usually involve gas chromatography—mass spectrometry or liquid chromatography-mass spectrometry. The use of gonadal steroids pre-dates their identification and isolation. Medical use of testicle extract began in the late 19th century while its effects on strength were still being studied. In the s, it was already known that the testes contain a more powerful androgen than androstenone , and three groups of scientists, funded by competing pharmaceutical companies in the Netherlands, Germany, and Switzerland, raced to isolate it.

The chemical synthesis of testosterone was achieved in August that year, when Butenandt and G. Wettstein, announced a patent application in a paper "On the Artificial Preparation of the Testicular Hormone Testosterone Androstenoneol. Clinical trials on humans, involving either oral doses of methyltestosterone or injections of testosterone propionate , began as early as Kennedy was administered steroids both before and during his presidency. The development of muscle-building properties of testosterone was pursued in the s, in the Soviet Union and in Eastern Bloc countries such as East Germany, where steroid programs were used to enhance the performance of Olympic and other amateur weight lifters.

In response to the success of Russian weightlifters, the U. The new steroid was approved for use in the U. It was most commonly administered to burn victims and the elderly. The drug's off-label users were mostly bodybuilders and weight lifters. Although Ziegler prescribed only small doses to athletes, he soon discovered that those having abused Dianabol suffered from enlarged prostates and atrophied testes. Three major ideas governed modifications of testosterone into a multitude of AAS: Androgens were discovered in the s and were characterized as having effects described as androgenic i.

Although anabolic steroid was originally intended to specifically describe testosterone-derived steroids with a marked dissociation of anabolic and androgenic effect, it is applied today indiscriminately to all steroids with AR agonism-based anabolic effects regardless of their androgenic potency, including even non-synthetic steroids like testosterone itself.

The legal status of AAS varies from country to country: Unlawful distribution or possession with intent to distribute AAS as a first offense is punished by up to ten years in prison. Those guilty of buying or selling AAS in Canada can be imprisoned for up to 18 months. In Canada, researchers have concluded that steroid use among student athletes is extremely widespread.

A study conducted in by the Canadian Centre for Drug-Free Sport found that nearly 83, Canadians between the ages of 11 and 18 use steroids. AAS are readily available without a prescription in some countries such as Mexico and Thailand. The history of the U. The same act also introduced more stringent controls with higher criminal penalties for offenses involving the illegal distribution of AAS and human growth hormone.

By the early s, after AAS were scheduled in the U. In the Controlled Substances Act, AAS are defined to be any drug or hormonal substance chemically and pharmacologically related to testosterone other than estrogens , progestins , and corticosteroids that promote muscle growth. The act was amended by the Anabolic Steroid Control Act of , which added prohormones to the list of controlled substances , with effect from January 20, In the United Kingdom, AAS are classified as class C drugs for their illegal abuse potential, which puts them in the same class as benzodiazepines.

Part 1 drugs are subject to full import and export controls with possession being an offence without an appropriate prescription. There is no restriction on the possession when it is part of a medicinal product. Part 2 drugs require a Home Office licence for importation and export unless the substance is in the form of a medicinal product and is for self-administration by a person.

Many other countries have similar legislation prohibiting AAS in sports including Denmark, [] France, [] the Netherlands [] and Sweden. United States federal law enforcement officials have expressed concern about AAS use by police officers. It's not that we set out to target cops, but when we're in the middle of an active investigation into steroids, there have been quite a few cases that have led back to police officers," says Lawrence Payne, a spokesman for the United States Drug Enforcement Administration.

Following the murder-suicide of Chris Benoit in , the Oversight and Government Reform Committee investigated steroid usage in the wrestling industry.

The documents stated that 75 wrestlers—roughly 40 percent—had tested positive for drug use since , most commonly for steroids. AAS are frequently produced in pharmaceutical laboratories, but, in nations where stricter laws are present, they are also produced in small home-made underground laboratories, usually from raw substances imported from abroad. As with most significant smuggling operations, organized crime is involved.

In the late s, the worldwide trade in illicit AAS increased significantly, and authorities announced record captures on three continents. In , Finnish authorities announced a record seizure of A year later, the DEA seized In the first three months of , Australian customs reported a record seizures of AAS shipments.

I joined the Nutrisystem plan because I knew I was headed in the wrong direction with my body weight. I decided to start going to a gym. However, I did not know how to start eating right. I pick the food I want to eat from the menu that Nutrisystem provides.

Nutrisystem also shows me how to plan what to eat for the day. The foods are really good. I love some of them, like most of them and only disliked one or two items out of the whole menu.

One of my favorite foods from Nutrisystem is their Mexican style tortilla soup, it's great. As far as diets go Nutrisystem is a great plan. When I was on the Nutrisystem plan it worked for me. I lost weight, learned to eat healthier and felt great. Nutrisystem is also extremely easy to follow. The plan comes with easy to follow instructions on how to use the program to work for you.

When I was on the plan my wife and children would eat their food while I ate my Nutrisystem food. Her food was hard to resist; however, I stuck to the Nutrisystem plan because their food also tastes good. I ate good food every day. Foods such as blueberry pancakes, blueberry muffins, honey mustard pretzel sticks, beef stew and broiled beef patties. Nutrisystem truly does go to great lengths to help make losing weight easy. I wanted to lose 20 pounds, but ended up shaving off 30 pounds thanks to Nutrisystem.

Nutrisystem is the best diet plan I have ever tried. I have tried to diet a few other times in my life but I could not stick to the diet. With Nutrisystem I do not have to learn recipes.

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Of course there are a few foods that do not suit my taste such as the eggs frittata; however, most of the foods are delicious. For breakfast I can eat pancakes, blueberry pancakes, cinnamon buns or oatmeal. There are many other breakfast foods to choose from also. For lunch I can eat hearty minestrone soup or choose from many other menu items. Nutrisystem also offers great dinners, snacks and desserts. Following the Nutrisystem plan is easy and I am seeing results.

I wish the weight melted off easier, but it took a while putting it on and so I expect it'll take time getting it off too. I had tried losing weight on my own a few times but it was too hard to count calories and weigh out all of my food what a time sucker!

I always got discouraged about losing the weight. With Nutrisystem I have not became discouraged because Nutrisystem makes the plan so simple to follow. While it's not fresh food the meals are frozen , it still just as great tasting. Speaking frankly, I was really afraid that I would hate the Nutrisystem food. I gave the food a try thinking it would taste like cardboard.

However, I was completely wrong, the Nutrisystem food is delicious. Breakfast, lunch, dinner, dessert and all my snacks provided by Nutrisystem are tasty. My wife loves me being on the Nutrisystem diet too.

She is very impressed with the progress I have made losing weight. She just makes dinner for the family and I eat my Nutrisystem meal.

Nutrisystem is a great diet plan that I personally think can help anyone lose weight. Let's be honest here, does any man like to cook? Not only do I not like to cook, I just don't have the time to cook.

That's why Nutrisystem really appealed to me when my doctor recommended it. I am a busy man who works 80 hours a week. I am also single. I just don't know how to cook, so I eat fast food quite often. I also eat at restaurants often too. The reason I go out to eat so often is because I am single, busy and do not know how to cook. Going out to eat is just easier than learning how to cook. But eating out is expensive and has caused me to quickly add on 30 pounds that I no longer wanted. I thought if I pay to go out to eat everyday I might as well pay to eat this healthy food and lose some weight.

The best part of the Nutrisystem plan is that I do not have to prepare the food and it still tastes great. I am losing weight eating healthy delicious foods.

I'm happy and so is my doctor who was telling me I needed to lose weight. I have lost nine pounds since I started the diet. With Nutrisystem you get to chose from many foods that are already prepared for you.

You also get a daily menu planner and a diary to log your success in. Nutrisystem also provides a website that includes articles, weight loss stories, blogs, chat rooms and a live counselor who is available 24 hours a day for support. With the Nutrisystem plan I go online everyday and log onto Nutrisystem's website to see my progress. I also check the discussion group forums and talk to other men who are trying to lose weight.

I enjoy using the Nutrisystem web site. The Nutrisystem plan is so simple to follow. I really can not think of any other diet plan that is as simple to use as Nutrisystem. The food Nutrisystem offers is also excellent. My favorite food from Nutrisystem is the beef stew. I love beef stew and I would not want to give it up for a diet. However, with Nutrisystem I do not have to give up beef stew because Nutrisystem offers a beef stew dinner. I have been on the plan for about one month now and have already lost seven pounds which wasn't happening with Bistro MD.

I'm happy to say that losing weight has never been easier. The Nutrisystem plan is very easy to follow and simple to understand. I get to eat three meals a day plus a snack and a dessert. As soon as I start to feel hungry I get to eat again. With Nutrisystem I get access to the Nutrisystem website tools too. The website is wonderful. I can log on and talk to other people from all over the world who are trying to lose weight.

The other people on the website inspire me to want to lose more weight and become even healthier. The people on the website inspire to me to stick with the plan until I reach my goal. It's a great support group.

The Nutrisystem website also provides me with access to a counselor who is available 24 hours a day to chat with if I have any questions. It's working for me and I know it will work for you too.

Now if I can only get my wife on it. I need more support! I have been using Nutrisystem's plan for about two months now. I thought for sure when I started the plan that I would probably have at least one thing to complain about it; however, I was wrong. Nutrisystem truly is a great plan. Any problems that you may read about online are obviously one off items and not a consistent trend. The basic plan is extremely easy to follow. It comes with specific instructions on how to follow it.

It also comes with some great dieting tools. The best part of the plan is that it comes with healthy foods that are already prepared for me to eat. Food wise, I love the vegetable beef soup; it is one of my favorite things to eat for lunch. I love to eat the chili with beans for dinner. So far, I love all of the foods I've tried. I haven't found one that wasn't edible. Even the desserts and snacks taste darn good. And unlike other diets, with Nutrisystem I don't crave junk food because I get a treat everyday in the meal plan: I have needed to lose weight for quite awhile and am just glad that I'm finally doing something about it.

I am very satisfied with the basic plan. Like most guys I know, I love to eat! I was always afraid of going on a hard core diet plan because I did not want to give up great tasting foods. With the Nutrisystem plan I have not had to give up any of my usual great tasting foods. Hats off to Nutrisystem for figuring out how to get great tasting food in a small package that is so easy to prepare - just stick it in the microwave and you're eating in 5 minutes.

So far, my favorite is the mushroom risotto, the chicken with dumplings, and the chili with beans, the flame broiled beef patty, the barbecue sauce pork wrap, the chocolate chocolate chip pudding, the chocolate crunch bar, the chocolate chip cookie, the creamy tomato sauce, the blueberry pancakes and the blueberry muffins. I could go on and on about the rest of Nutrisystem's dishes but I'm making myself hungry ;- I enjoy eating all of Nutrisystem's foods.

I do not think I have found a food that I did not like yet. Do not be afraid of having to give up eating great food because you're still going to get great food with Nutrisystem. Nutrisystem is a great diet plan for anyone - especially men.

I get to eat great food that is already prepared for me everyday. All I have to do is follow the basic directions for following the plan and eat the Nutrisystem foods. The best part about the Nutrisystem plan is that I lost seven pounds since I started it a month ago.

Nutrisystem also supplies its members with a member website. The website helps individuals on the plan stay motivated. The website is a place where anyone who is on the plan can go for support. I enjoy logging onto the website and seeing the progress that I have made. I also enjoy reading inspiring stories from others on the Nutrisystem plan that have lost weight. Luckily though, Nutrisystem offers many different foods to choose from.

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After all, who can't throw an extra dish in the microwave for 5 minutes? Give it a try guys and I expect your girlfriend will be just as happy as mine is. I have lost 20 pounds in three months and haven't been exercising at all.

Just like their marketing says, the plan really does allow you to eat healthy while losing weight. The foods are very easy to clean up when I am finished also. Just throw the microwave safe container in the trash.

What more could you ask for? I take my frozen lunch with me to work and I can get more work done while losing weight! The plan is also very simple to follow, just follow their instructions. Don't deviate by eating snickers bars, okay?! Stay away from those evil vending machines too! If you drink coffee, stop using creamer as I discovered I was drinking an extra calories a day in coffee creamer! The Nutrisystem plan is great for men who do not know how to cook and want to lose weight, feel healthier and eat healthier.

Since starting the diet, I've lost 20 pounds and have started feeling good about my body again, which has helped my love life significantly. My girlfriend can't keep her hands off of my new slimmer waist ;- She is so proud of me and she thinks I look great. Who would have thought I could eat healthy food that I do not have to prepare that I actually like?

I am a married man who needed to lose weight. My wife told me I should try Nutrisystem because I could lose weight while eating good tasting food. She also thought the plan sounded good because she would not have to cook special foods for me while I was dieting.

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Nutrisystem is a simple way to lose weight. Fingers crossed I can keep it off when I go off of Nutrisystem. Nutrisystem is diet plan that allows a person to lose weight without having to think too much about it.

I haven't tried any of the other plans, but I can tell you this, the basic plan is super easy to follow. It comes with diet tools that are easy to use and awesome tasting foods albeit frozen.

As they say in the support forum, it's all about taking it one day at a time and doing your best to stick with the meal plans and not deviate, which is hard to do if you have co-workers that want to eat out for lunch all the time. The plan has helped me look better and feel great about myself.

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